Hypoxic Exercise Training Elevates Erythrocyte Aggregation

Pathological erythrocyte aggregation reduces capillary perfusion and oxygen transfer to tissue, which is determined by the negative surface charge on membrane (intrinsic aggregability) fibrinogen–erythrocyte interaction (extrinsic factor). Exercise-induced oxidative stress important for rheological adaptation training but may also cause senescence. This study clarifies effects of hypoxic exercise intrinsic/extrinsic factors aggregation. In total, 60 healthy sedentary males were randomly assigned either (HE; FIO2 = 0.15) or normoxic (NE; 0.21) groups 30 min·d−1, 5 d·wk−1 6 weeks at % maximum work rate a control group (CTL). A hypoxia test (HET, 0.12) was performed before after intervention. Erythrocyte assessed ektacytometry, fibrinogen binding affinity senescence biomarkers flow cytometry. An acute 12% HET significantly enhanced global through intrinsic aggregability. Resting promoted both aggregability probability force HE, whereas NE mainly associated with ameliorated interactions. The still facilitated HE because augmented fibrinogen-related factors, even though factor suppressed. Additionally, further increased reticulocyte counts while reducing expression CD47 CD147. extrinsic an fibrinogen. Although accelerated turnover observed, led